The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

Many analogies exist between the process of evolution by natural selection and of learning by reinforcement and punishment. A full extension of the evolutionary analogy to learning to include analogues of the fitness, genotype, development, environmental influences, and phenotype concepts makes possible a single theory of the learning process able to encompass all of the elementary procedures known to yield learning.

The interaction of the organism with the environment requires not only reactive, but also active behavior which helps subject to meet the challenge of the uncertainty of the environment. A positive feedback between active behavior and immune system makes the selection process effective.

Hull et al.'s analysis of operant behavior in terms of interaction and replication does not seem consistent with a genuine selection model. The putative replicators do not replicate, and the overall process is more reminiscent of directed mutation than of natural selection. General analogies between natural selection and operant reinforcement are too superficial to be of much scientific use.

In their account of learning and behavior, the authors define an interactor as emitted behavior that operates on the environment, which excludes Pavlovian learning. A unified neural-network account of the operant-Pavlovian dichotomy favors interpreting neurons as interactors and synaptic efficacies as replicators. The latter interpretation implies that single-synapse change is inherently Lamarckian.

Activity anorexia illustrates selection of behavior at the biological, behavioral, and neural levels. Based on evolutionary history, food depletion increases the reinforcement value of physical activity that, in turn, decreases the reinforcement effectiveness of eating – resulting in activity anorexia. Neural opiates participate in the selection of physical activity during periods of food depletion.

Seeking parallels among disciplines can have both risks and benefits. Finding parallels may be a vacuous exercise in categorization, generating no new insights. And pointing to analogous functions may cause us to treat them as homologous. Hull et al. have provided a basis for the generation of insights in different selectionist areas, without confusing analogy with homology.

Company–community agreements are widely considered to be a practical mechanism for recognising the rights, needs and priorities of peoples impacted by mining, for managing impacts and ensuring that mining-derived benefits are shared. The use and application of company–community agreements is increasing globally. Notwithstanding the utility of these agreements, the gender dimensions of agreement processes in mining have rarely been studied. Prior research on women and mining demonstrates that women are often more adversely impacted by mining than men, and face greater (...) challenges in accessing development opportunities that mining can bring. Nonetheless, there is currently little guidance for companies, government or communities in bringing a gender perspective to the fore in mining and agreement processes. It is undisputed in human development literature that investment in women and sensitivity to gender delivers long-term health, education and local development outcomes. In mining and development, a number of key factors remain unexplored. These include: women’s participation in agreement processes, the gendered distribution of agreement benefits, and the extent to which impacts and benefits influence women’s development and economic inclusion. This paper presents the results of the first phase of an applied research project undertaken by the Centre for Social Responsibility in Mining at The University of Queensland and funded by the Minerals Council of Australia and the Department of Foreign Affairs and Trade. The project sought to connect with experienced practitioners who had been directly involved in mining and agreement processes to document and analyse grounded perspectives on gender dynamics and agreements, and connect those experiences with the broader literature. Findings from this study have implications for the role of mining companies and governments in promoting gender equality and empowerment as part of their commitments to sustainable development. They also have implications for community groups and their representatives in terms of how they might engage in agreement processes to maximise women’s participation and influence. In many social contexts, a key challenge will be navigating the territory of cultural norms and gender equality, particularly in cultures where women’s influence in the public sphere is not strong. The authors argue that without consideration of a gender perspective, including gender’s intersection with other factors such as class, race, poverty level, ethnic group and age, mining agreements will not be inclusive, may exacerbate gender inequalities, and fail to contribute to long-term sustainable development. (shrink)

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor (...) evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation. (shrink)

It is predicted that the rapid acquisition of new genetic knowledge and related applications during the next decade will have significant implications for virtually all members of society. Currently, most people get exposed to information about genes and genetics only through stories publicized in the media. We sought to understand how individuals in the general population used and understood the concepts of ???genetics??? and ???genes.??? During in-depth one-on-one telephone interviews with adults in the United States, we asked questions exploring their (...) basic understanding of these terms, as well as their belief as to the location of genes in the human body. A wide range of responses was received. Despite conversational familiarity with genetic terminology, many noted frustration or were hesitant when trying to answer these questions. In addition, some responses reflected a lack of understanding about basic genetic science that may have significant implications for broader public education measures in genetic literacy, genetic counseling, public health practices, and even routine health care. (shrink)

BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

This book is a detailed and challenging brief for the view that Paul Tillich was fundamentally an atheist seeking to convert fellow Christians to the humanistic faith to which he himself was converted in his days as a university student. The "God above God" is simply humanity; and an ultimate concern which is not demonic must be one that is "transparent to humanity," that really amounts to a devotedness to all of humanity. The author does not write this from the (...) viewpoint of a theist protesting Tillich's views, but from that of an atheist rather dubious about the advantages of his method. While the strategic use of ambiguity and obscure symbols is said to have enabled Tillich to work within Christianity for the subversion of belief in any God above man and nature, his work seems oddly to have provided less penetrating readers with motives for retaining their supernatural beliefs. The author is an economist and political scientist, not a philosopher or theologian. Still he has studied Tillich and his sources carefully, and in his study he gives a good survey of the literature about Tillich. In this survey he underlines the interesting point that most orthodox theists find Tillich a believer, but immensely obscure; while most atheistic interpreters find it very clear that Tillich is an atheist. The author does not have an especially subtle understanding of the classical expression of theism. For example, he finds "the crucial question" to be: Does being itself have mental attributes resembling those of a person? But his weaknesses here do not totally invalidate the work: Wheat assigns a very large defensive task to theistic interpreters of Tillich.--R. D. L. (shrink)

This introduction to moral philosophy treats a wide range of theoretical questions and a number of contemporary moral problems. The first chapter discusses the noncognitivism of many analytic ethicians [[sic]], and insists on the possibility of providing correct and interpersonally valid answers to a number of disputed moral issues. Chapter two treats basic issues concerning freedom and moral responsibility; and the third chapter discusses the difficulties raised by the naturalistic fallacy argument. Chapters four and five distinguish the author's "reflective naturalism" (...) from other moral positions. While there is some appeal to Dewey and others in the American naturalist tradition, the author is a naturalist more in the realistic tradition of Thomism. There is some lack of clarity in the exposition of his own basic position because of a desire to associate too closely the naturalism of Thomas with that of Dewey. The practical issues treated are those of sexual morality, of economic life, and political life. These questions are treated intelligently, and enter into lively debate with some leading opponents of a sophisticated and liberal Christian ethical position. But the arguments do not succeed so clearly in presenting themselves as decisively valid answers flowing out of the basic principles of his fundamental position. The final chapter is a critique of the closed, anti-theistic elements of Dewey's naturalism, and an appeal for a naturalism open to theistic influence.--R. D. L. (shrink)

This small anthology contains thirteen essays by eleven authors on the question: What are the defining characteristics of morality? What makes a judgment, an attitude, or an argument a moral one? The selection of articles is excellent. Ethicians included are: C. H. Whitely, A. MacIntyre, W. K. Frankena, C. C. W. Taylor, Neil Cooper, P. F. Strawson, T. L. S. Sprigge, P. Foot, K. Baier, G. E. M. Anscombe, D. F. Gauthier. An obvious objection to the pursuit of a definition (...) would be to suggest, as Whitely does, that there are no defining traits for all uses of "moral" or "morality": one can hope only to find family resemblances in the uses of the words. Others insist that there is a more precise and consistent use of these notions in ordinary language, though there may be different senses of the word moral, each with sufficiently clear defining traits. In a useful introduction that provides a unifying background for the essays, the editors suggest that six chief candidates appear for the role of the leading characteristic of morality: moral rules and principles can be defined by reference to their capacity for universality, their prescriptivity, their overriding force, the importance they have, the forms of sanctions appealed to, or by reference to their content. The authors in their essays do not, of course, define morality simply in terms of any one of these features; but they do stress or deny the importance of each of these features. Students will find this a helpful work, and there is a good bibliography.--R. D. L. (shrink)